Analysis Of The Risks Posed By The Decline In Human Genetic Diversity To The Sustainability Of Future Development
DOI:
https://doi.org/10.47134/jasim.v1i2.2158Keywords:
Genetic diversity, Global health, Precision medicine, human sustainabilityAbstract
Human genetic variation plays a crucial role in enhancing disease resistance, adaptive capacity, and future survival. This study aims to analyze the impact of declining human genetic diversity and its implications for global health, disease resilience, and social equity. This study is based on a literature review of historical population bottlenecks, colonization processes, and the underrepresentation of certain populations in modern genomic research. The analysis reveals that disparities in access to healthcare and the dominance of European population data in genomic databases have widened scientific gaps and hindered the development of inclusive precision medicine. Furthermore, this study examines various examples from history, contemporary genomic databases, and international initiatives such as H3Africa and the Human Pangenome Project to demonstrate that the decline in human genetic variation can increase vulnerability to pandemics and hereditary diseases, as well as reduce human adaptive capacity to global environmental changes. Therefore, a systemic evaluation of health research governance, the distribution of scientific benefits, and collaborative policies that ensure the equitable involvement of the entire human population is necessary.
References
Allendorf, F. W., & Luikart, G. (2013). Conservation and the genetics of populations (2nd ed.). Wiley-Blackwell. https://www.wiley.com/en-us/Conservation+and+the+Genetics+of+Populations%2C+2nd+Edition-p-9781444339895
Ambrose, S. H. (1998). Late Pleistocene human population bottlenecks, volcanic winter, and differentiation of modern humans. Journal of Human Evolution, 34(6), 623–651. https://doi.org/10.1006/jhev.1998.0219
Frankham, R., Ballou, J. D., & Briscoe, D. A. (2010). Introduction to conservation genetics (2nd ed.). Cambridge University Press. https://www.cambridge.org/highereducation/books/introduction-to-conservation-genetics/696B4E558C93F7FBF9C33D6358EA7425
Hawks, J., Cochran, G., Harpending, H., & Moyzis, R. (2007). Recent acceleration of human adaptive evolution. Proceedings of the National Academy of Sciences, 104(52), 20753–20758. https://doi.org/10.1073/pnas.0707650104
Martin, A. R., et al. (2019). Clinical use of current polygenic risk scores may exacerbate health disparities. Nature Genetics, 51, 584–591. https://doi.org/10.1038/s41588-019-0379-x
O’Fallon, B. D., & Jorde, L. B. (2006). Genetic evidence for a recent population expansion in humans. Genetics, 172(1), 259–264. https://doi.org/10.1534/genetics.105.048391
Popejoy, A. B., & Fullerton, S. M. (2016). Genomics is failing on diversity. Nature, 538, 161–164. https://doi.org/10.1038/538161a
Quintana-Murci, L. (2016). Human immunology through the lens of evolutionary genetics. Cell, 177(1), 274–291. https://doi.org/10.1016/j.cell.2019.02.033
Rosenberg, N. A., et al. (2002). Genetic structure of human populations. Science, 298, 2381–2385. https://doi.org/10.1126/science.1078311
Reich, D., et al. (2012). Reconstructing Native American population history. Nature, 488, 370–374. https://doi.org/10.1038/nature11258
Rotimi, C., & Tishkoff, S. (2014). The Human Heredity and Health in Africa (H3Africa) Initiative. Science, 344, 1346–1348. https://doi.org/10.1126/science.1252217
Sirugo, G., Williams, S. M., & Tishkoff, S. A. (2019). The missing diversity in human genetic studies. Cell, 177(1), 26–31. https://doi.org/10.1016/j.cell.2019.02.048
Tishkoff, S. A., & Kidd, K. K. (2004). Implications of biogeography of human populations for “race” and medicine. Nature Genetics, 36(s1), S21–S27. https://doi.org/10.1038/ng1435
1000 Genomes Project Consortium. (2015). A global reference for human genetic variation. Nature, 526, 68–74. https://doi.org/10.1038/nature15393
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